Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.63 |
| ▸ | UBE2M | P61081 | 8/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184160 | 1.00 | CHEK2 (0.63) | CHEK2UBE2MDCUN1D1JAK2JAK3 | |
| SCHEMBL183846 | 0.89 | CHEK2 (0.58) | CHEK2UBE2MDCUN1D1JAK2JAK3 | |
| SCHEMBL183845 | 0.89 | CHEK2 (0.58) | CHEK2UBE2MDCUN1D1JAK2JAK3 | |
| SCHEMBL5506872 | 0.88 | CHEK2 (0.68) | CHEK2JAK2JAK3MAPT | |
| SCHEMBL4015698 | 0.88 | CHEK2 (0.68) | CHEK2JAK2JAK3MAPT | |
| SCHEMBL1621663 | 0.88 | CHEK2 (0.60) | CHEK2CCR5KCNH2MAPT | |
| Hydrochloric Acid SCHEMBL1624310 | 0.87 | CHEK2 (0.59) | CHEK2CCR5KCNH2MAPT | |
| SCHEMBL1623249 | 0.86 | CHEK2 (0.62) | CHEK2JAK2JAK3MAPT | |
| SCHEMBL1622398 | 0.83 | CHEK2 (0.56) | CHEK2MAPT | |
| SCHEMBL4021314 | 0.83 | CHEK2 (0.56) | CHEK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |