Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 2/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNK | O75909 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CDK7 | P50613 | 3/20 | 0.43 |
| ▸ | CCNH | P51946 | 3/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841479 | 0.95 | KMT2A (0.46) | HSD11B1CDK2CCNKCCNA2CDK7 | |
| SCHEMBL1141937 | 0.87 | SYK (0.47) | HSD11B1IDH1IDH2CYP3A4SYK | |
| SCHEMBL1141940 | 0.87 | SYK (0.47) | HSD11B1IDH1IDH2CYP3A4SYK | |
| SCHEMBL1838867 | 0.85 | CYP3A4 (0.47) | HSD11B1IDH1IDH2CYP3A4SYK | |
| SCHEMBL1141551 | 0.84 | KMT2A (0.47) | SYKHCRTR1KMT2A | |
| SCHEMBL1141554 | 0.84 | KMT2A (0.47) | SYKHCRTR1KMT2A | |
| SCHEMBL1141175 | 0.82 | SYK (0.46) | SYKHCRTR1HCRTR2KMT2A | |
| SCHEMBL1141173 | 0.82 | SYK (0.46) | SYKHCRTR1HCRTR2KMT2A | |
| SCHEMBL1841481 | 0.80 | HCRTR1 (0.44) | HSD11B1IDH1IDH2CDK12CYP3A4 | |
| SCHEMBL1838142 | 0.77 | CCNK (0.47) | CDK2CCNKCCNA2CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-11 | — | — | EP | disclosed |
| WO-2009133522-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-05 | — | — | WO | disclosed |