Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 14/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 14/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.46 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CCNH | P51946 | 4/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838881 | 0.88 | KMT2A (0.45) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1141278 | 0.86 | CCNK (0.44) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1141276 | 0.86 | CCNK (0.44) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1838876 | 0.85 | EGFR (0.44) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1838143 | 0.84 | CCNK (0.42) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1141607 | 0.83 | HCRTR1 (0.49) | — | |
| SCHEMBL1141606 | 0.83 | HCRTR1 (0.49) | — | |
| SCHEMBL1838864 | 0.77 | HSD11B1 (0.48) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1838879 | 0.74 | EGFR (0.43) | CCNKCDK12CDK2CCNA2CDK7 | |
| SCHEMBL1841479 | 0.72 | KMT2A (0.46) | CCNKCDK12CDK2CCNA2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-11 | — | — | EP | claimed |
| WO-2009133522-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-05 | — | — | WO | claimed |
| EP-2318367-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-11 | — | — | EP | disclosed |
| WO-2009133522-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-05 | — | — | WO | disclosed |