Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838143 | 0.85 | CCNK (0.42) | CCNKCCNA2CDK2CDK7CCNH | |
| SCHEMBL1838876 | 0.84 | EGFR (0.44) | EGFRJAK3ITKKMT2ACCNK | |
| SCHEMBL1838881 | 0.81 | KMT2A (0.45) | EGFRJAK3ITKKMT2ACCNK | |
| SCHEMBL1141607 | 0.80 | HCRTR1 (0.49) | KMT2AHCRTR1GFERPOLB | |
| SCHEMBL1141606 | 0.80 | HCRTR1 (0.49) | KMT2AHCRTR1GFERPOLB | |
| SCHEMBL1835674 | 0.79 | MAP3K12 (0.49) | KMT2AHCRTR1 | |
| SCHEMBL1838142 | 0.74 | CCNK (0.47) | CCNKCCNA2CDK2CDK7CCNH | |
| SCHEMBL3818132 | 0.74 | CCNK (0.47) | EGFRJAK3ITKKMT2ACCNK | |
| SCHEMBL3818135 | 0.74 | CCNK (0.47) | EGFRJAK3ITKKMT2ACCNK | |
| SCHEMBL3821865 | 0.73 | CCNK (0.46) | EGFRJAK3ITKKMT2ACCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-11 | — | — | EP | disclosed |