Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 5/20 | 0.32 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | KIF5B | P33176 | 3/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17142297 | 1.00 | PDE1B (0.37) | PDE1BPDE1APDE1CCHRM4CCNT1 | |
| SCHEMBL17142270 | 1.00 | PDE1B (0.37) | PDE1BPDE1APDE1CCHRM4CCNT1 | |
| SCHEMBL16822550 | 0.87 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE4BKDM4E | |
| SCHEMBL17154328 | 0.86 | PDE1A (0.37) | PDE1BPDE1APDE1CCHRM4EGFR | |
| SCHEMBL17142268 | 0.79 | PDE1B (0.48) | PDE1BPDE1APDE1CCHRM4EGFR | |
| SCHEMBL17142302 | 0.76 | PDE1B (0.52) | PDE1BPDE1APDE1CCCNT1CDK9 | |
| SCHEMBL17142244 | 0.73 | JAK2 (0.47) | PDE1BPDE1APDE1CTSHRKCNH2 | |
| SCHEMBL16822569 | 0.73 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE4BKDM4E | |
| SCHEMBL17142299 | 0.70 | CYP1A2 (0.45) | EGFRMAPTTSHRHSD17B10 | |
| SCHEMBL17142254 | 0.70 | PDE1B (0.37) | PDE1BPDE1APDE1CCHRM4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126354-B1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-01-22 | — | — | EP | disclosed |
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-05-16 | — | — | US | disclosed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | disclosed |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | PDE12, PDE3A, PDE7B | PDE1B 15/4885PDE1A 13/4885PDE1C 38/4885 |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE7B | PDE1B 15/4885PDE1A 13/4885PDE1C 38/4885 |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE7B | PDE1B 15/4885PDE1A 13/4885PDE1C 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.