Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822558 | 0.87 | PDE1B (0.51) | JAK2JAK1ADORA3ADORA2AADORA2B | |
| SCHEMBL16822559 | 0.87 | PDE1B (0.51) | JAK2JAK1ADORA3ADORA2AADORA2B | |
| SCHEMBL16822617 | 0.87 | PDE1B (0.51) | JAK2JAK1ADORA3ADORA2AADORA2B | |
| SCHEMBL17142294 | 0.86 | JAK2 (0.47) | JAK2JAK1ADORA3ADORA2AADORA2B | |
| SCHEMBL17142254 | 0.79 | PDE1B (0.37) | JAK2JAK1IRAK4USP2LMNA | |
| SCHEMBL17142296 | 0.74 | ELOVL1 (0.44) | JAK2JAK1BRAFLMNAPDE1A | |
| SCHEMBL18394840 | 0.73 | PDE1B (0.37) | TSHRKCNH2PDE1APDE1BPDE1C | |
| SCHEMBL17142270 | 0.73 | PDE1B (0.37) | TSHRKCNH2PDE1APDE1BPDE1C | |
| SCHEMBL17142297 | 0.73 | PDE1B (0.37) | TSHRKCNH2PDE1APDE1BPDE1C | |
| SCHEMBL17142268 | 0.70 | PDE1B (0.48) | PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126354-B1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-01-22 | — | — | EP | claimed |
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-05-16 | — | — | US | claimed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | claimed |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-01-26 | — | — | US | claimed |
| EP-3126354-B1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-01-22 | — | — | EP | disclosed |
| EP-3126354-B1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-01-22 | — | — | EP | disclosed |
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-05-16 | — | — | US | disclosed |
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-05-16 | — | — | US | disclosed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | disclosed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | disclosed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | disclosed |
| EP-3126354-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2017-02-08 | — | — | EP | disclosed |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-01-26 | — | — | US | disclosed |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-01-26 | — | — | US | disclosed |
| WO-2015150254-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-10-08 | — | — | WO | disclosed |
| WO-2015150254-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | PDE12, PDE3A, PDE7B | JAK2 3020/4885JAK1 521/4885ADORA3 2180/4885 |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE7B | JAK2 3020/4885JAK1 521/4885ADORA3 2180/4885 |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE7B | JAK2 3020/4885JAK1 521/4885ADORA3 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.