Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398263 | 0.87 | NPC1 (0.40) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398308 | 0.86 | MAPT (0.40) | NPC1RAB9AALDH1A1KMT2ATP53 | |
| SCHEMBL18398419 | 0.86 | CFTR (0.38) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398361 | 0.85 | JAK2 (0.40) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398424 | 0.81 | GPR6 (0.39) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398203 | 0.80 | GPR6 (0.37) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398299 | 0.80 | PDE4A (0.38) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18409202 | 0.80 | TYK2 (0.53) | ALDH1A1TSHRMAPK1LMNAHSD17B10 | |
| SCHEMBL18398542 | 0.80 | GPR6 (0.40) | CFTRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18398471 | 0.78 | JAK2 (0.52) | CFTRNPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |