Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409287 | 0.85 | JAK2 (0.47) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18398581 | 0.85 | JAK2 (0.53) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18409203 | 0.85 | JAK2 (0.39) | TYK2JAK1JAK2JAK3CASP1 | |
| SCHEMBL18398230 | 0.84 | TYK2 (0.56) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18409114 | 0.84 | TYK2 (0.46) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18409285 | 0.84 | TYK2 (0.62) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18409103 | 0.82 | JAK2 (0.43) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL18409108 | 0.81 | JAK1 (0.47) | TYK2JAK1JAK2JAK3ABL1 | |
| SCHEMBL18398306 | 0.80 | CFTR (0.39) | TYK2JAK1JAK2JAK3ALDH1A1 | |
| SCHEMBL18409176 | 0.79 | TYK2 (0.48) | TYK2JAK1JAK2JAK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |