Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398452 | 0.85 | JAK2 (0.42) | JAK2JAK1TYK2JAK3HRH4 | |
| SCHEMBL18398607 | 0.85 | JAK2 (0.45) | MAPK14GRIN2BJAK2JAK1TYK2 | |
| SCHEMBL18398309 | 0.79 | PPARG (0.45) | LMNA | |
| SCHEMBL18398295 | 0.79 | MAP2K2 (0.40) | MAPK14ABCB11NQO2MAP2K2MAP2K1 | |
| SCHEMBL18409345 | 0.79 | JAK2 (0.50) | MAPK14JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398336 | 0.78 | JAK2 (0.38) | JAK2JAK1TYK2JAK3HRH4 | |
| SCHEMBL18398406 | 0.77 | JAK2 (0.60) | MAPK14JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398478 | 0.77 | JAK2 (0.38) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL15184316 | 0.76 | GRIN2B (0.35) | GRIN2BJAK2JAK1TYK2JAK3 | |
| SCHEMBL18398278 | 0.75 | JAK2 (0.36) | JAK2JAK1TYK2JAK3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |