Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | SMC2 | O95347 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.37 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398296 | 0.85 | JAK2 (0.37) | MAP2K2MAP2K1ABCB11NQO2SMC2 | |
| SCHEMBL18398418 | 0.84 | MAP2K2 (0.38) | MAP2K2MAP2K1ABCB11NQO2SMC2 | |
| SCHEMBL18398577 | 0.79 | JAK2 (0.48) | SYKKCNH2 | |
| SCHEMBL18398493 | 0.79 | PPARG (0.46) | EGLN1LMNAPKM | |
| SCHEMBL18409114 | 0.79 | TYK2 (0.46) | MAPK14ABL1 | |
| SCHEMBL18398530 | 0.79 | MAPK14 (0.36) | MAP2K2MAP2K1ABCB11NQO2MAPK14 | |
| SCHEMBL18398396 | 0.76 | JAK1 (0.44) | MAP2K2MAP2K1ABCB11NQO2SMC2 | |
| SCHEMBL15175025 | 0.75 | GABRG2 (0.41) | LMNAP2RX7 | |
| SCHEMBL18398495 | 0.72 | MAPT (0.43) | LMNAP2RX7PKM | |
| SCHEMBL18398607 | 0.71 | JAK2 (0.45) | MAP2K2MAP2K1ABCB11NQO2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |