Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399589 | 0.89 | HDAC3 (0.42) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL22853573 | 0.89 | HDAC3 (0.42) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL19059670 | 0.89 | HDAC3 (0.42) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL20368736 | 0.89 | HDAC3 (0.42) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL22138687 | 0.85 | HDAC1 (0.46) | HDAC3HDAC1HDAC2TSHRCETP | |
| SCHEMBL22853730 | 0.83 | SMN1; SMN2 (0.45) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL22018237 | 0.83 | ADCY1 (0.42) | HDAC3HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL22018432 | 0.81 | HDAC3 (0.42) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL19059690 | 0.81 | HDAC3 (0.41) | HDAC3HDAC1HDAC2ABL1TSHR | |
| SCHEMBL18399552 | 0.81 | HDAC3 (0.41) | HDAC3HDAC1HDAC2ABL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550765-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-01-24 | — | — | US | disclosed |