Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PON1 | P27169 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359458 | 0.87 | PON1 (0.61) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL1102259 | 0.81 | CA9 (0.62) | ALDH1A1KDM4ECA9CA1CA12 | |
| SCHEMBL31290721 | 0.77 | ALDH1A1 (0.68) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL757926 | 0.77 | ALDH1A1 (0.68) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL958685 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL29419327 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL12181806 | 0.77 | PON1 (0.45) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL2708072 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| Water SCHEMBL11848480 | 0.75 | ALDH1A1 (0.96) | ALDH1A1KDM4EKMT2ACA9CA1 | |
| SCHEMBL12251339 | 0.75 | HSD17B3 (0.65) | ALDH1A1KDM4EKMT2AMAPTPON1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550771-B2 | Keto-imidazopyridine derivatives as RORc modulators | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |