Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.57 |
| ▸ | ACAT1 | P24752 | 2/20 | 0.57 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.49 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18400790 | 0.90 | DGAT1 (0.65) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL18400787 | 0.90 | DGAT1 (0.64) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969286 | 0.89 | DGAT1 (0.70) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969391 | 0.85 | DGAT1 (0.62) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969305 | 0.84 | DGAT1 (0.59) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969236 | 0.83 | DGAT1 (0.65) | DGAT1ACAT1 | |
| SCHEMBL18400828 | 0.82 | DGAT1 (0.78) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969193 | 0.81 | DGAT1 (0.54) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL15638674 | 0.81 | DGAT1 (0.81) | DGAT1ACAT1SOAT1DGAT2 | |
| SCHEMBL16969172 | 0.79 | DGAT1 (0.57) | DGAT1ACAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550793-B2 | Spirocyclic compounds, compositions and medicinal applications thereof | ADVINUS THERAPEUTICS LIMITED (IN) | 2017-01-24 | — | — | US | disclosed |