Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 4/20 | 0.40 |
| ▸ | MIF | P14174 | 8/20 | 0.40 |
| ▸ | CD74 | P04233 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18402539 | 0.85 | MIF (0.48) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18402538 | 0.84 | TSHR (0.62) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16296691 | 0.76 | MIF (0.49) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16296741 | 0.74 | TSHR (0.63) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18402541 | 0.73 | TSHR (0.65) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17312335 | 0.71 | TSHR (0.59) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16296797 | 0.63 | TSHR (0.78) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2757835 | 0.63 | MIF (0.71) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14563049 | 0.62 | MAPT (0.58) | IDO1MIFCD74KMT2APOLB | |
| SCHEMBL17312297 | 0.62 | TSHR (0.63) | TSHRHTTSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |