Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.89 |
| ▸ | KDR | P35968 | 2/20 | 0.74 |
| ▸ | AURKA | O14965 | 1/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.74 |
| ▸ | INSR | P06213 | 1/20 | 0.74 |
| ▸ | FBP1 | P09467 | 1/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.74 |
| ▸ | FLT4 | P35916 | 1/20 | 0.74 |
| ▸ | CLK1 | P49759 | 1/20 | 0.74 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.74 |
| ▸ | TEK | Q02763 | 1/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22336746 | 0.92 | EGFR (0.94) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL16295327 | 0.91 | EGFR (0.78) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13497930 | 0.91 | EGFR (0.79) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL17327991 | 0.89 | EGFR (0.78) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13524614 | 0.88 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL30520472 | 0.88 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL18655499 | 0.87 | EGFR (0.85) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL15217639 | 0.87 | EGFR (0.82) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL20305795 | 0.87 | EGFR (0.74) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL14092460 | 0.87 | EGFR (0.92) | EGFRKDRAURKAERBB2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |