Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 20/20 | 0.62 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.41 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.41 |
| ▸ | DMPK | Q09013 | 1/20 | 0.41 |
| ▸ | EPHA7 | Q15375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18403354 | 0.90 | MAP3K12 (0.62) | MAP3K12MAP3K13NTRK1CSF1RAXL | |
| SCHEMBL19937925 | 0.88 | MAP3K12 (0.61) | MAP3K12MAP3K13NTRK1CSF1RAXL | |
| SCHEMBL19937929 | 0.82 | MAP3K12 (0.58) | MAP3K12 | |
| SCHEMBL18403299 | 0.82 | MAP3K12 (0.58) | MAP3K12 | |
| SCHEMBL18403366 | 0.82 | MAP3K12 (0.58) | MAP3K12 | |
| SCHEMBL18403305 | 0.82 | MAP3K12 (0.58) | MAP3K12 | |
| SCHEMBL18403242 | 0.81 | MAP3K12 (0.63) | MAP3K12MAP3K13NTRK1CSF1RAXL | |
| SCHEMBL22137474 | 0.81 | MAP3K12 (0.63) | MAP3K12MAP3K13NTRK1CSF1RAXL | |
| SCHEMBL19937903 | 0.78 | MAP3K12 (0.63) | MAP3K12MAP3K13NTRK1CSF1RAXL | |
| SCHEMBL18403309 | 0.78 | MAP3K12 (0.63) | MAP3K12MAP3K13NTRK1CSF1RAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550777-B2 | 3-substituted pyrazoles and use as DLK inhibitors | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |