Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PTPRC | P08575 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780425 | 0.94 | KDM4E (0.56) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL600772 | 0.89 | KDM4E (0.62) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL29395845 | 0.89 | KDM4E (0.62) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL25184674 | 0.88 | SMN1; SMN2 (0.62) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL4910550 | 0.87 | KDM4E (0.64) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL1285808 | 0.87 | NPC1 (0.63) | KDM4EHPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2984329 | 0.87 | KMT2A (0.60) | KDM4EHPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL31148337 | 0.87 | HDAC1 (0.61) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL24990754 | 0.87 | TP53BP1 (0.55) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC | |
| SCHEMBL5672219 | 0.87 | L3MBTL1 (0.66) | KDM4EHPGDSMN1; SMN2ALDH1A1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | disclosed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | disclosed |
| US-4018743-A | Process for preparing triketoimidazolidines | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117760-A1 | Dna minor groove binding compounds | PCNA, POLL, POLM | KDM4E 4120/4885HPGD 2766/4885SMN1; SMN2 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.