Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841396 | 0.95 | HRAS (0.57) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1842807 | 0.95 | HRAS (0.57) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL5750249 | 0.86 | HRAS (0.66) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1841119 | 0.84 | HRAS (0.48) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1843135 | 0.83 | HDAC1 (0.52) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1842028 | 0.82 | HDAC1 (0.42) | KDM4EPOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL1842667 | 0.82 | HDAC1 (0.42) | KDM4EPOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL5750357 | 0.81 | HRAS (0.58) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1842079 | 0.81 | HRAS (0.55) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL1842054 | 0.80 | HRAS (0.49) | HRASESR1TOP1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | claimed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | claimed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | claimed |
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | disclosed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | disclosed |
| EP-1467969-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | The University of Strathclyde (GB) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059881-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIVERSITY OF STRATHCLYDE (GB) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117760-A1 | Dna minor groove binding compounds | PCNA, POLL, POLM | HRAS 2839/4885ESR1 3299/4885TOP1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.