Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 7/20 | 0.66 |
| ▸ | ESR1 | P03372 | 7/20 | 0.66 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.66 |
| ▸ | TOP1 | P11387 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750357 | 0.95 | HRAS (0.58) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1841396 | 0.92 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1842807 | 0.92 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1842079 | 0.89 | HRAS (0.55) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1842682 | 0.89 | HRAS (0.55) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1842273 | 0.89 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5447288 | 0.87 | HDAC1 (0.56) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL1840563 | 0.86 | HRAS (0.49) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL18089498 | 0.85 | HDAC1 (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL2398688 | 0.85 | HDAC1 (0.54) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |