Urea

Urea

SCHEMBL1840735

CCCCCC1CCCCC1.NC(N)=O.NC(N)=O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.65
SIGMAR1 Q99720 3/20 0.50
HTT P42858 2/20 0.44
LMNA P02545 1/20 0.44
MAPK1 P28482 1/20 0.44
PKM P14618 1/20 0.44
EPHX1 P07099 1/20 0.44
NAAA Q02083 3/20 0.43
METAP2 P50579 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL1837240 0.98 CYP1A2 (0.63) CYP1A2SIGMAR1HTTEPHX1NAAA
Butylcyclohexane SCHEMBL1838223 0.94 CYP1A2 (0.75) CYP1A2SIGMAR1HTTLMNAMAPK1
Bicarbonate SCHEMBL5183166 0.90 CYP1A2 (0.68) CYP1A2SIGMAR1HTTPKMEPHX1
Bicarbonate SCHEMBL9562968 0.88 CYP1A2 (0.65) CYP1A2SIGMAR1HTTEPHX1NAAA
Bicarbonate SCHEMBL4782415 0.88 CYP1A2 (0.65) CYP1A2SIGMAR1HTTEPHX1NAAA
SCHEMBL8750956 0.88 CYP1A2 (0.65) CYP1A2SIGMAR1HTTPKMEPHX1
Propionic Acid SCHEMBL3879824 0.88 CYP1A2 (0.65) CYP1A2SIGMAR1HTTPKMEPHX1
Methyl Alcohol SCHEMBL8960609 0.87 CYP1A2 (0.77) CYP1A2SIGMAR1HTTLMNAMAPK1
SCHEMBL25394046 0.87 CYP1A2 (0.85) CYP1A2SIGMAR1EPHX1NAAA
SCHEMBL7733130 0.87 CYP1A2 (0.85) CYP1A2SIGMAR1EPHX1NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2322504-B9 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER ASAHI CHEMICAL IND (JP) 2017-09-06 EP disclosed
EP-2322504-B1 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER ASAHI CHEMICAL IND (JP) 2016-09-28 EP disclosed
US-9249090-B2 N-substituted carbamic acid ester production method and isocyanate production method using the N-substituted carbamic acid ester ASAHI KASEI CHEMICALS CORPORATION (JP) 2016-02-02 US disclosed
US-20150038742-A1 N-Substituted Carbamic Acid Ester Production Method and Isocyanate Production Method Using the N-Substituted Carbamic Acid Ester ASAHI KASEI CHEMICALS CORPORATION (JP) 2015-02-05 US disclosed
US-8884047-B2 N-substituted carbamic acid ester production method and isocyanate production method using the N-substituted carbamic acid ester ASAHI KASEI CHEMICALS CORPORATION (JP) 2014-11-11 US disclosed
US-20110160476-A1 N-Substituted Carbamic Acid Ester Production Method and Isocyanate Production Method Using the N-Substituted Carbamic Acid Ester ASAHI KASEI CHEMICALS CORPORATION (JP) 2011-06-30 US disclosed
EP-2322504-A1 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER Asahi Kasei Chemicals Corporation (JP) 2011-05-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110160476-A1 N-Substituted Carbamic Acid Ester Production Method and Isocyanate Production Method Using the N-Substituted Carbamic Acid Ester ALKBH3, CPS1, APEH CYP1A2 121/4885SIGMAR1 2888/4885HTT 423/4885
US-20150038742-A1 N-Substituted Carbamic Acid Ester Production Method and Isocyanate Production Method Using the N-Substituted Carbamic Acid Ester ALKBH3, CPS1, APEH CYP1A2 121/4885SIGMAR1 2888/4885HTT 423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.