Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12105431 | 0.86 | HSD11B1 (0.50) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL12105417 | 0.86 | HSD11B1 (0.50) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL12372019 | 0.86 | HSD11B1 (0.50) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1206270 | 0.85 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL1207690 | 0.85 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL1205978 | 0.81 | GRIN2D (0.56) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1205945 | 0.81 | GRIN2D (0.56) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13753189 | 0.81 | GRIN2D (0.56) | HSD11B1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1207588 | 0.81 | NR1H2 (0.52) | HSD11B1 | |
| SCHEMBL2561234 | 0.80 | HSD11B1 (0.47) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220048-B1 | ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2017-01-25 | — | — | EP | disclosed |