Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | HRAS | P01112 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | DNM1L | O00429 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533232 | 0.97 | HDAC1 (0.44) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1844965 | 0.88 | HDAC1 (0.51) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL10690267 | 0.88 | HDAC1 (0.51) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL10693709 | 0.88 | HDAC1 (0.51) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1841398 | 0.85 | HDAC1 (0.45) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1842682 | 0.85 | HRAS (0.55) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1841620 | 0.84 | HDAC1 (0.45) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL6783410 | 0.84 | HDAC1 (0.45) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1843622 | 0.84 | HDAC1 (0.44) | HDAC1HDAC2HDAC8PRKCAHRAS | |
| SCHEMBL1844512 | 0.83 | HDAC1 (0.45) | HDAC1HDAC2HDAC8PRKCAHRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | disclosed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117760-A1 | Dna minor groove binding compounds | PCNA, POLL, POLM | HDAC1 356/4885HDAC2 1194/4885HDAC8 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.