Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 5/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409328 | 0.88 | NR1H4 (0.38) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18398185 | 0.87 | JAK2 (0.36) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL18409548 | 0.79 | JAK2 (0.48) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL18409121 | 0.79 | JAK2 (0.48) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL18409107 | 0.78 | JAK2 (0.53) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18398537 | 0.78 | CTSL (0.44) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL18409171 | 0.78 | SMN1; SMN2 (0.43) | NR1H4SMN1; SMN2NPSR1KDM4EHTT | |
| SCHEMBL18409120 | 0.78 | JAK2 (0.38) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL18409164 | 0.77 | JAK2 (0.42) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18398536 | 0.77 | JAK2 (0.42) | JAK2JAK1TYK2JAK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |