Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | TYK2 | P29597 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398581 | 0.88 | JAK2 (0.53) | JAK2JAK1TYK2JAK3DYRK1A | |
| SCHEMBL18409286 | 0.83 | JAK2 (0.47) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409204 | 0.81 | JAK2 (0.45) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18398321 | 0.80 | IKBKB (0.37) | JAK1TYK2ALDH1A1MAPTTNIK | |
| SCHEMBL18409176 | 0.80 | TYK2 (0.48) | JAK2JAK1TYK2JAK3DYRK1A | |
| SCHEMBL18409133 | 0.79 | TYK2 (0.42) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398390 | 0.79 | ITK (0.39) | ALDH1A1MAPTDYRK1AADORA2A | |
| SCHEMBL18398461 | 0.78 | JAK2 (0.36) | JAK2JAK1TYK2JAK3ABCC9 | |
| SCHEMBL15174569 | 0.76 | PRKDC (0.43) | JAK2JAK1TYK2JAK3ABCC9 | |
| SCHEMBL18409106 | 0.74 | KMT2A (0.35) | JAK2JAK1TYK2JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |