Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.53 |
| ▸ | TYK2 | P29597 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409176 | 0.91 | TYK2 (0.48) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409205 | 0.88 | JAK2 (0.40) | JAK2JAK1TYK2JAK3EGLN2 | |
| SCHEMBL18409114 | 0.87 | TYK2 (0.46) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409287 | 0.86 | JAK2 (0.47) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409202 | 0.85 | TYK2 (0.53) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409285 | 0.85 | TYK2 (0.62) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409158 | 0.83 | TYK2 (0.58) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409133 | 0.82 | TYK2 (0.42) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409365 | 0.81 | GSK3B (0.44) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL18409117 | 0.79 | TYK2 (0.55) | JAK2JAK1TYK2JAK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |