Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409171 | 0.88 | SMN1; SMN2 (0.43) | TSPOSMN1; SMN2ALDH1A1CCNE2CCNE1 | |
| SCHEMBL2771027 | 0.87 | CCNE2 (0.38) | TSPOSMN1; SMN2ALDH1A1CCNE2CCNE1 | |
| SCHEMBL18409115 | 0.86 | POLB (0.40) | TSPOSMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL18409118 | 0.85 | CCNE2 (0.36) | TSPOSMN1; SMN2ALDH1A1CCNE2CCNE1 | |
| SCHEMBL18409177 | 0.81 | CCNE2 (0.36) | TSPOSMN1; SMN2ALDH1A1CCNE2CCNE1 | |
| SCHEMBL3039547 | 0.77 | MCL1 (0.36) | TSPOSMN1; SMN2ALDH1A1CCNE2CCNE1 | |
| SCHEMBL18409257 | 0.76 | JAK2 (0.36) | TSPOSMN1; SMN2ALDH1A1TSHRMAPK1 | |
| SCHEMBL18409146 | 0.75 | CCNE2 (0.42) | SMN1; SMN2ALDH1A1TSHRCCNE2CCNE1 | |
| SCHEMBL1512298 | 0.75 | POLB (0.37) | SMN1; SMN2ALDH1A1TSHRHTTMEN1 | |
| SCHEMBL2767424 | 0.73 | CCNE1 (0.67) | SMN1; SMN2ALDH1A1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |