Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSPO | P30536 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409112 | 0.89 | KMT2A (0.40) | POLBHSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL1512298 | 0.88 | POLB (0.37) | POLBHSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL18409256 | 0.86 | TSPO (0.46) | HSP90AA1GAAKMT2AMEN1TSPO | |
| SCHEMBL18409259 | 0.86 | MEN1 (0.40) | POLBHSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL18409179 | 0.84 | SLC6A2 (0.36) | POLBHSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL18398190 | 0.79 | POLB (0.35) | POLBKMT2AMEN1TSPOTDP1 | |
| SCHEMBL18409106 | 0.79 | KMT2A (0.35) | POLBKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL1512303 | 0.78 | POLB (0.36) | POLBHSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL18409258 | 0.78 | S1PR1 (0.38) | POLBGAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL18398637 | 0.77 | JAK2 (0.37) | POLBKMT2AMEN1TSPOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |