Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409282 | 0.90 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409289 | 0.89 | JAK2 (0.41) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL18409346 | 0.89 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409107 | 0.88 | JAK2 (0.53) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL18409326 | 0.86 | JAK2 (0.41) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409283 | 0.86 | JAK2 (0.34) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409290 | 0.83 | MEN1 (0.32) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409109 | 0.83 | JAK2 (0.39) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409264 | 0.83 | JAK2 (0.39) | JAK2JAK1TYK2JAK3POLB | |
| SCHEMBL18409542 | 0.83 | JAK2 (0.36) | JAK2JAK1TYK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |