Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409282 | 0.89 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409102 | 0.88 | LMNA (0.33) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL18409346 | 0.86 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409281 | 0.86 | JAK2 (0.39) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18398428 | 0.84 | MAPT (0.36) | LMNAPPARGALDH1A1TSHRMAPT | |
| SCHEMBL18409326 | 0.84 | JAK2 (0.41) | JAK2JAK1TYK2JAK3PPARG | |
| SCHEMBL18409290 | 0.81 | MEN1 (0.32) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409289 | 0.81 | JAK2 (0.41) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409109 | 0.81 | JAK2 (0.39) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL18409294 | 0.81 | LMNA (0.33) | JAK2JAK1TYK2JAK3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |