Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.37 |
| ▸ | JAK1 | P23458 | 10/20 | 0.37 |
| ▸ | TYK2 | P29597 | 10/20 | 0.37 |
| ▸ | JAK3 | P52333 | 10/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409260 | 0.93 | JAK2 (0.36) | JAK2JAK1TYK2JAK3GABRG2 | |
| SCHEMBL18409113 | 0.88 | ALDH1A1 (0.36) | GABRG2GABRB3GABRA5PIK3CAMEN1 | |
| SCHEMBL18409289 | 0.86 | JAK2 (0.41) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409164 | 0.85 | JAK2 (0.42) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409541 | 0.84 | PIK3CA (0.35) | JAK2JAK1TYK2JAK3GABRG2 | |
| SCHEMBL18409180 | 0.84 | TYK2 (0.35) | JAK2JAK1TYK2JAK3GABRG2 | |
| SCHEMBL18409110 | 0.83 | POLB (0.33) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL18409564 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CHEK1 | |
| SCHEMBL18409360 | 0.82 | MEN1 (0.36) | GABRG2GABRB3GABRA5PIK3CAMEN1 | |
| SCHEMBL18409321 | 0.82 | JAK2 (0.38) | JAK2JAK1TYK2JAK3NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |