Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180987 | 0.86 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL180779 | 0.67 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL180680 | 0.66 | DGAT1 (0.56) | DGAT1 | |
| SCHEMBL1448295 | 0.66 | HTR2C (0.51) | DGAT1MCHR1FASN | |
| SCHEMBL180995 | 0.65 | DGAT1 (0.61) | PTPN1PTPN2DGAT1MCHR1 | |
| SCHEMBL180840 | 0.65 | DGAT1 (0.53) | DGAT1 | |
| SCHEMBL180755 | 0.65 | DGAT1 (0.49) | PTPN1PTPN2DGAT1MCHR1 | |
| SCHEMBL180908 | 0.65 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL180846 | 0.65 | DGAT1 (0.60) | DGAT1 | |
| SCHEMBL180618 | 0.65 | DGAT1 (0.67) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402317-A1 | DGAT inhibitor | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |