Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1475184 | 0.83 | ALDH1A1 (0.36) | GAAPDE8BALDH1A1POLBKDM5B | |
| SCHEMBL29339901 | 0.83 | KDM5B (0.33) | GAAPDE8BKDM5BCYP2C19ABL1 | |
| SCHEMBL26686143 | 0.81 | GAA (0.44) | GAAPDE8BALDH1A1LMNAPOLB | |
| SCHEMBL30376074 | 0.78 | KDM5B (0.36) | GAAPDE8BALDH1A1LMNAPOLB | |
| SCHEMBL18421834 | 0.78 | ALDH1A1 (0.33) | GAAALDH1A1KDM5BCYP2C19TP53 | |
| SCHEMBL11913135 | 0.76 | ABL1 (0.33) | GAAALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL1476580 | 0.76 | — | — | |
| SCHEMBL23457143 | 0.75 | ELANE (0.39) | GAAALDH1A1LMNACYP2C19TP53 | |
| SCHEMBL18209661 | 0.74 | ALDH1A1 (0.34) | GAAALDH1A1LMNAPOLBKDM5B | |
| SCHEMBL14313780 | 0.74 | ALDH1A1 (0.40) | GAAALDH1A1LMNAPOLBKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829484-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2020-11-10 | — | — | US | disclosed |
| US-10829484-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2020-11-10 | — | — | US | disclosed |
| WO-2017019804-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2017-02-02 | — | — | WO | disclosed |
| US-20170029413-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2017-02-02 | — | — | US | disclosed |
| US-20170029413-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2017-02-02 | — | — | US | disclosed |
| US-20170029413-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2017-02-02 | — | — | US | disclosed |
| WO-2017019804-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029413-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K11, PRKAR2B, MAP3K13 | GAA 3244/4885PDE8B 395/4885ALDH1A1 4034/4885 |
| US-10829484-B2 | Compounds and methods for kinase modulation, and indications therefor | MAP3K11, PRKAR2B, MAP3K13 | GAA 3244/4885PDE8B 395/4885ALDH1A1 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.