SCHEMBL18424992

SCHEMBL18424992

NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SCc2ccccc2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 20/20 1.00
▸ CA2 P00918 20/20 1.00
▸ CA6 P23280 20/20 1.00
▸ CA7 P43166 20/20 1.00
▸ CA13 Q8N1Q1 20/20 1.00
▸ CA9 Q16790 19/20 1.00
▸ CA1 P00915 19/20 1.00
▸ CA14 Q9ULX7 18/20 1.00
▸ CA5B Q9Y2D0 18/20 1.00
▸ CA4 P22748 17/20 1.00
▸ CA5A P35218 16/20 1.00
▸ CA3 P07451 9/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31670532 1.00 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18425713 0.85 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18424835 0.84 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18425872 0.83 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL31670543 0.83 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18425351 0.82 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18425844 0.80 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18425618 0.80 CA2 (0.69) CA12CA2CA6CA7CA13
SCHEMBL18424116 0.79 CA12 (1.00) CA12CA2CA6CA7CA13
SCHEMBL18426004 0.79 CA2 (1.00) CA12CA2CA6CA7CA13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3328833-B1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE UNIV VILNIUS (LT) 2025-08-06 — — EP claimed
US-11312682-B2 Selective inhibitors of carbonic anhydrase VILNIUS UNIVERSITY (LT) 2022-04-26 — — US claimed
US-20180222856-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE VILNIUS UNIVERSITY (LT) 2018-08-09 — — US claimed
EP-3328833-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE Vilnius University (LT) 2018-06-06 — — EP claimed
WO-2017017505-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE VILNIUS UNIVERSITY (LT) 2017-02-02 — — WO claimed
EP-3328833-B1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE UNIV VILNIUS (LT) 2025-08-06 — — EP disclosed
US-11312682-B2 Selective inhibitors of carbonic anhydrase VILNIUS UNIVERSITY (LT) 2022-04-26 — — US disclosed
US-20180222856-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE VILNIUS UNIVERSITY (LT) 2018-08-09 — — US disclosed
EP-3328833-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE Vilnius University (LT) 2018-06-06 — — EP disclosed
WO-2017017505-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE VILNIUS UNIVERSITY (LT) 2017-02-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11312682-B2 Selective inhibitors of carbonic anhydrase CA2, CA9, CA7 CA12 8/4885CA2 1/4885CA6 5/4885
US-20180222856-A1 SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE CA9, CA2, CA7 CA12 8/4885CA2 2/4885CA6 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback