Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.90 |
| ▸ | KDR | P35968 | 2/20 | 0.83 |
| ▸ | AURKA | O14965 | 1/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.76 |
| ▸ | INSR | P06213 | 1/20 | 0.76 |
| ▸ | FBP1 | P09467 | 1/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.76 |
| ▸ | FLT4 | P35916 | 1/20 | 0.76 |
| ▸ | CLK1 | P49759 | 1/20 | 0.76 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.76 |
| ▸ | TEK | Q02763 | 1/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10883 | 0.94 | EGFR (1.00) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL17520337 | 0.92 | EGFR (1.00) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL2102985 | 0.92 | EGFR (1.00) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL14092460 | 0.91 | EGFR (0.92) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13562523 | 0.91 | EGFR (0.90) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL11727 | 0.91 | EGFR (1.00) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL8623 | 0.91 | EGFR (1.00) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13529196 | 0.91 | EGFR (0.98) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL30520472 | 0.90 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13524614 | 0.90 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124025-B1 | COMBINATION BETWEEN 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL] METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE AND AN EGFR TYR-KINASE INHIBITOR | SERVIER LAB (FR) | 2018-02-28 | — | — | EP | disclosed |
| EP-3124025-A1 | COMBINATION BETWEEN 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL] METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE AND AN EGFR TYR-KINASE INHIBITOR | Les Laboratoires Servier (FR) | 2017-02-01 | — | — | EP | disclosed |