Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122523 | 0.67 | CYP1A2 (0.44) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL30449012 | 0.67 | CYP1A2 (0.44) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL17537376 | 0.66 | CYP1A2 (0.58) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL29223912 | 0.66 | CYP1A2 (0.61) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL21393614 | 0.65 | CYP1A2 (0.41) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL29588226 | 0.65 | CYP1A2 (0.48) | CYP1A2HTTGAAMAPTKDM4E | |
| SCHEMBL12289345 | 0.65 | CYP1A2 (0.48) | CYP1A2HTTGAAMAPTKDM4E | |
| SCHEMBL21394064 | 0.64 | GAA (0.40) | CYP1A2HTTGAABRD9MAPT | |
| SCHEMBL6780438 | 0.63 | ADRB1 (0.49) | MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5534269 | 0.63 | CYP1A2 (0.54) | CYP1A2HTTGAABRD9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315756-A2 | 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010005958-A2 | 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2010-01-14 | — | — | WO | disclosed |