Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436276 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL23377290 | 0.85 | ALDH1A1 (0.49) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL19998609 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL19012701 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL19001073 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL15546192 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL16835552 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL18436518 | 0.79 | KMT2A (0.47) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL18436325 | 0.79 | KMT2A (0.47) | KDM4EALDH1A1GAAKMT2ALRRK2 | |
| SCHEMBL22169617 | 0.78 | KMT2A (0.44) | KDM4EALDH1A1GAAKMT2ALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |