Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.76 |
| ▸ | RAF1 | P04049 | 16/20 | 0.76 |
| ▸ | ARAF | P10398 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15085295 | 0.87 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL19879433 | 0.87 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL18435598 | 0.82 | BRAF (0.73) | BRAFRAF1ARAFKDR | |
| SCHEMBL20404684 | 0.80 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL18435808 | 0.80 | BRAF (0.65) | BRAFRAF1ARAFKDRMAPK14 | |
| SCHEMBL18435612 | 0.79 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL18435607 | 0.79 | BRAF (0.58) | BRAFRAF1ARAF | |
| SCHEMBL17931847 | 0.76 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL20614988 | 0.74 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL18435558 | 0.73 | BRAF (0.79) | BRAFRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124472-B1 | FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS | BEIGENE LTD (KY) | 2018-07-25 | — | — | EP | disclosed |
| EP-3124472-A1 | FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS | BeiGene, Ltd. (KY) | 2017-02-01 | — | — | EP | disclosed |