Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 1.00 |
| ▸ | RAF1 | P04049 | 18/20 | 1.00 |
| ▸ | ARAF | P10398 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15085295 | 1.00 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL17931847 | 0.88 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL20614988 | 0.87 | BRAF (0.78) | BRAFRAF1ARAF | |
| SCHEMBL18436122 | 0.87 | BRAF (0.76) | BRAFRAF1ARAF | |
| SCHEMBL20324231 | 0.84 | BRAF (0.72) | BRAFRAF1ARAF | |
| SCHEMBL20323725 | 0.83 | BRAF (0.70) | BRAFRAF1ARAF | |
| SCHEMBL15085303 | 0.81 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL19879401 | 0.81 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL21480845 | 0.81 | BRAF (0.68) | BRAFRAF1ARAF | |
| SCHEMBL30495369 | 0.81 | BRAF (0.73) | BRAFRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895376-B2 | Fused tricyclic compounds as Raf kinase inhibitors | BEIGENE, LTD. (KY) | 2018-02-20 | — | — | US | disclosed |