Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436159 | 0.85 | MAPT (0.51) | MAPTMAPK1L3MBTL1KDM4EGAA | |
| SCHEMBL7731838 | 0.76 | MAPT (0.41) | POLBMAPTMAPK1L3MBTL1GAA | |
| SCHEMBL13105502 | 0.72 | POLB (0.45) | POLBMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13105218 | 0.72 | POLB (0.45) | POLBMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11935557 | 0.69 | POLB (0.36) | POLBMAPT | |
| SCHEMBL11936069 | 0.69 | GAA (0.47) | POLBMAPTMAPK1L3MBTL1KDM4E | |
| SCHEMBL11940094 | 0.69 | POLB (0.36) | POLBMAPT | |
| SCHEMBL13105592 | 0.69 | GAA (0.47) | POLBMAPTMAPK1L3MBTL1KDM4E | |
| SCHEMBL11940092 | 0.69 | POLB (0.36) | POLBMAPT | |
| SCHEMBL11935568 | 0.69 | POLB (0.36) | POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |