Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436182 | 0.85 | POLB (0.36) | MAPTKDM4EALDH1A1KMT2ARAB9A | |
| SCHEMBL18436160 | 0.83 | MAPT (0.57) | MAPTLRRK2KDM4EALDH1A1RAB9A | |
| SCHEMBL13624236 | 0.78 | MAPT (0.51) | MAPTLRRK2KMT2ARAB9A | |
| SCHEMBL13716397 | 0.77 | MAPT (0.63) | MAPTLRRK2KMT2ARAB9A | |
| SCHEMBL18436424 | 0.76 | MAPT (0.58) | MAPTLRRK2KMT2ARAB9A | |
| SCHEMBL17128163 | 0.76 | MAPT (0.58) | MAPTLRRK2KMT2ARAB9A | |
| SCHEMBL7731838 | 0.75 | MAPT (0.41) | MAPTALDH1A1KMT2ARAB9AGAA | |
| SCHEMBL13105197 | 0.73 | MAPT (0.66) | MAPTLRRK2ALDH1A1KMT2ARAB9A | |
| SCHEMBL13105222 | 0.73 | MAPT (0.66) | MAPTLRRK2ALDH1A1KMT2ARAB9A | |
| SCHEMBL11941158 | 0.71 | MAPT (0.47) | MAPTLRRK2KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |