Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17128002 | 0.91 | SMO (0.53) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL21336678 | 0.91 | SMO (0.53) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL18436226 | 0.91 | FASN (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL21336718 | 0.91 | FASN (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL18436696 | 0.91 | FASN (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL17128371 | 0.91 | FASN (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL18436939 | 0.79 | SMO (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL17127016 | 0.79 | SMO (0.42) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL21336886 | 0.79 | SMO (0.55) | FASNPPARGSMOPGRGPR183 | |
| SCHEMBL17128029 | 0.79 | SMO (0.55) | FASNPPARGSMOPGRGPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |