Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 5/20 | 0.42 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17128371 | 1.00 | FASN (0.42) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL18436696 | 1.00 | FASN (0.42) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL21336718 | 1.00 | FASN (0.42) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL18436227 | 0.91 | FASN (0.44) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL18436939 | 0.89 | SMO (0.42) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL17127016 | 0.89 | SMO (0.42) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL21336678 | 0.88 | SMO (0.53) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL17128002 | 0.88 | SMO (0.53) | FASNSMOPGRGPR183PPARG | |
| SCHEMBL18436105 | 0.81 | CHRM1 (0.43) | SMOCHRM1CHRM2EGLN1PARP1 | |
| SCHEMBL17128172 | 0.81 | CHRM1 (0.43) | SMOCHRM1CHRM2EGLN1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |