Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19012397 | 0.91 | SMO (0.46) | POLBACHEPLA2G1BATG4BHSD11B1 | |
| SCHEMBL18436771 | 0.91 | SMO (0.46) | POLBACHEPLA2G1BATG4BHSD11B1 | |
| SCHEMBL19012460 | 0.91 | SMO (0.46) | POLBACHEPLA2G1BATG4BHSD11B1 | |
| SCHEMBL19000977 | 0.87 | MEN1 (0.48) | POLBHSD11B1ALDH1A1HPGDLMNA | |
| SCHEMBL19000979 | 0.87 | MEN1 (0.48) | POLBHSD11B1ALDH1A1HPGDLMNA | |
| SCHEMBL19001088 | 0.87 | MEN1 (0.48) | POLBHSD11B1ALDH1A1HPGDLMNA | |
| SCHEMBL19012398 | 0.87 | KDM4E (0.44) | POLBACHEHSD11B1SLC6A7ALDH1A1 | |
| SCHEMBL19012400 | 0.87 | SMO (0.44) | ACHEPLA2G1BATG4BHSD11B1SLC6A7 | |
| SCHEMBL18436935 | 0.83 | SMN1; SMN2 (0.47) | POLBALDH1A1USP2MAPK1CYP3A4 | |
| SCHEMBL18435999 | 0.83 | ACHE (0.49) | POLBACHEPLA2G1BATG4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |