SCHEMBL18436555

SCHEMBL18436555

C=C(C)C(=O)Oc1ccc(-c2cc(=O)c3cc(OC)ccc3o2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.70
TP53 P04637 7/20 0.70
CYP3A4 P08684 5/20 0.70
KDM4E B2RXH2 4/20 0.70
ALDH1A1 P00352 4/20 0.70
HPGD P15428 4/20 0.70
NPC1 O15118 3/20 0.70
RAB9A P51151 3/20 0.70
HSD17B10 Q99714 3/20 0.70
NFKB1 P19838 2/20 0.70
NFKB2 Q00653 2/20 0.70
RELA Q04206 2/20 0.70
RXFP1 Q9HBX9 2/20 0.70
LMNA P02545 2/20 0.70
THRB P10828 2/20 0.70
SMN1; SMN2 Q16637 2/20 0.70
MEN1 O00255 4/20 0.68
KMT2A Q03164 4/20 0.68
CYP2C9 P11712 3/20 0.68
CYP2C19 P33261 3/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9607679 0.95 MAPT (0.70) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL2301029 0.94 MAPT (0.60) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL21091108 0.88 MAPT (0.68) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL18468323 0.88 MAPT (0.68) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL21417969 0.88 MAPT (0.78) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL18468341 0.88 MAPT (0.53) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL13609779 0.87 ABCB1 (0.65) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL18869502 0.87 MAPT (0.57) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL19157960 0.87 MAPT (0.60) MAPTTP53CYP3A4KDM4EALDH1A1
SCHEMBL18517353 0.87 MAPT (0.54) MAPTTP53CYP3A4KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219656-A1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS Merck Patent GmbH (DE) 2023-08-02 EP disclosed
EP-4209566-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2023-07-12 EP disclosed
EP-4209567-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2023-07-12 EP disclosed
EP-4209568-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2023-07-12 EP disclosed
EP-4194529-A1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS Merck Patent GmbH (DE) 2023-06-14 EP disclosed
EP-3944011-A1 LIQUID-CRYSTAL DISPLAY Merck Patent GmbH (DE) 2022-01-26 EP disclosed
EP-3848436-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2021-07-14 EP disclosed
EP-3604481-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2021-05-26 EP disclosed
EP-3730591-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2020-10-28 EP disclosed
EP-3353261-B1 METHOD OF CONTROLLING THE PRETILT ANGLE IN POLYMER STABILISED LIQUID CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2020-05-27 EP disclosed
EP-3428246-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-01-16 EP disclosed
EP-2703472-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2018-07-04 EP disclosed
EP-2985334-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-06-20 EP disclosed
EP-3284803-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2018-02-21 EP disclosed
EP-3029127-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2017-12-20 EP disclosed
EP-2993216-B1 COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-07-26 EP disclosed
EP-2628779-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-05-17 EP disclosed
EP-2990459-B1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2017-04-26 EP disclosed
EP-3130651-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2017-02-15 EP disclosed
EP-2922933-B1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2017-02-01 EP disclosed