Azacitidine

Azacitidine

SCHEMBL1843658

Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1.O=C(O)c1ccccc1.O=C(O)c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DNMT1DNMT3A

The experimentally established mechanism targets of Azacitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 known ✓ P26358 2/20 0.79
LMNA P02545 2/20 0.79
MTOR P42345 2/20 0.79
TP53 P04637 2/20 0.79
THPO P40225 2/20 0.79
GMNN O75496 1/20 0.79
ALDH1A1 P00352 1/20 0.79
NFKB1 P19838 1/20 0.79
HTT P42858 1/20 0.79
RAB9A P51151 1/20 0.79
BLM P54132 1/20 0.79
HBB P68871 1/20 0.79
PMP22 Q01453 1/20 0.79
THRB P10828 1/20 0.56
MDM2 Q00987 1/20 0.56
NCOA1 Q15788 1/20 0.56
NCOA3 Q9Y6Q9 1/20 0.56
MAPT P10636 2/20 0.52
TDP1 Q9NUW8 1/20 0.52
KDM4E B2RXH2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azacitidine SCHEMBL29269051 1.00 LMNA (0.79) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL17537438 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL169369 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL706302 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL10024703 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL23815524 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL13390797 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Fazarabine SCHEMBL3278 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL1249475 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO
Azacitidine SCHEMBL19996985 0.89 LMNA (1.00) LMNAMTORTP53DNMT1THPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9416152-B2 Azacitidine process and polymorphs DR. REDDY'S LABORATORIES LTD. (IN) 2016-08-16 US disclosed
US-20140155588-A1 AZACITIDINE PROCESS AND POLYMORPHS DR. REDDY'S LABORATORIES INC. (US) 2014-06-05 US disclosed
US-8703932-B2 Azacitidine process and polymorphs DR. REDDY'S LABORATORIES LTD. (IN) 2014-04-22 US disclosed
US-20110201800-A1 AZACITIDINE PROCESS AND POLYMORPHS DR. REDDY'S LABORATORIES LTD. (IN) 2011-08-18 US disclosed
EP-2321302-A2 AZACITIDINE PROCESS AND POLYMORPHS Dr. Reddy's Laboratories Ltd. (IN) 2011-05-18 EP disclosed
WO-2010014883-A2 AZACITIDINE PROCESS AND POLYMORPHS DR. REDDY'S LABORATORIES LTD. (IN) 2010-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155588-A1 AZACITIDINE PROCESS AND POLYMORPHS AZI2, DNMT3A, DCTD DNMT1 4/4885LMNA 1813/4885MTOR 1488/4885
US-20110201800-A1 AZACITIDINE PROCESS AND POLYMORPHS AZI2, DNMT3A, DCTD DNMT1 4/4885LMNA 1979/4885MTOR 1619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.