Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azacitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 known ✓ | P26358 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | MTOR | P42345 | 2/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.79 |
| ▸ | THPO | P40225 | 2/20 | 0.79 |
| ▸ | GMNN | O75496 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.79 |
| ▸ | HBB | P68871 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azacitidine SCHEMBL29269051 | 1.00 | LMNA (0.79) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL17537438 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL169369 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL706302 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL10024703 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL23815524 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL13390797 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Fazarabine SCHEMBL3278 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL1249475 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO | |
| Azacitidine SCHEMBL19996985 | 0.89 | LMNA (1.00) | LMNAMTORTP53DNMT1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416152-B2 | Azacitidine process and polymorphs | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-08-16 | — | — | US | disclosed |
| US-20140155588-A1 | AZACITIDINE PROCESS AND POLYMORPHS | DR. REDDY'S LABORATORIES INC. (US) | 2014-06-05 | — | — | US | disclosed |
| US-8703932-B2 | Azacitidine process and polymorphs | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-04-22 | — | — | US | disclosed |
| US-20110201800-A1 | AZACITIDINE PROCESS AND POLYMORPHS | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-08-18 | — | — | US | disclosed |
| EP-2321302-A2 | AZACITIDINE PROCESS AND POLYMORPHS | Dr. Reddy's Laboratories Ltd. (IN) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010014883-A2 | AZACITIDINE PROCESS AND POLYMORPHS | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155588-A1 | AZACITIDINE PROCESS AND POLYMORPHS | AZI2, DNMT3A, DCTD | DNMT1 4/4885LMNA 1813/4885MTOR 1488/4885 |
| US-20110201800-A1 | AZACITIDINE PROCESS AND POLYMORPHS | AZI2, DNMT3A, DCTD | DNMT1 4/4885LMNA 1979/4885MTOR 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.