Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436350 | 0.78 | AR (0.36) | AR | |
| SCHEMBL15273739 | 0.77 | BCHE (0.34) | AR | |
| SCHEMBL15261520 | 0.77 | BCHE (0.31) | — | |
| SCHEMBL17703309 | 0.75 | CTSK (0.37) | — | |
| SCHEMBL15261612 | 0.75 | HTR2C (0.36) | — | |
| Hydrochloric Acid SCHEMBL15261504 | 0.74 | HTR2C (0.36) | — | |
| SCHEMBL10953037 | 0.70 | — | — | |
| SCHEMBL24914928 | 0.69 | KDM4E (0.33) | — | |
| SCHEMBL19805376 | 0.68 | HDAC8 (0.31) | AR | |
| SCHEMBL15261449 | 0.68 | OPRL1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822953-B9 | MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | PFIZER (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-2822953-B1 | MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | PFIZER (US) | 2017-02-01 | — | — | EP | disclosed |