Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001099 | 0.78 | SMO (0.39) | SMOHRH3OGACNR1CNR2 | |
| SCHEMBL19012353 | 0.78 | SMO (0.39) | SMOHRH3OGACNR1CNR2 | |
| SCHEMBL17128345 | 0.76 | OGA (0.50) | SMOHRH3OGAOPRD1MAPT | |
| Hydrochloric Acid SCHEMBL28341448 | 0.75 | OGA (0.49) | SMOHRH3OGAOPRD1MAPT | |
| SCHEMBL1471033 | 0.74 | MAPT (0.41) | CNR1CNR2HDAC11MAPTALDH1A1 | |
| SCHEMBL19012378 | 0.71 | OGA (0.51) | SMOHRH3OGAMAPTALDH1A1 | |
| SCHEMBL29977962 | 0.70 | PIM1 (0.39) | SMOHRH3OGAOPRD1MAPT | |
| SCHEMBL18436110 | 0.70 | PIM1 (0.39) | SMOHRH3OGAOPRD1MAPT | |
| SCHEMBL17128127 | 0.70 | HTR2C (0.39) | SMOHRH3OGAOPRD1 | |
| Hydrochloric Acid SCHEMBL29978429 | 0.69 | PIM1 (0.39) | SMOHRH3OGAOPRD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |