Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 11/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436776 | 0.85 | HRH4 (0.35) | EP300FAAH | |
| SCHEMBL1727148 | 0.73 | KDM4E (0.47) | FAAH | |
| SCHEMBL17128066 | 0.71 | ENPP1 (0.40) | KDM4AKDM5B | |
| SCHEMBL17128326 | 0.70 | CNR2 (0.46) | CNR2 | |
| SCHEMBL17128422 | 0.70 | CNR2 (0.46) | CNR2 | |
| SCHEMBL17128203 | 0.68 | IRAK4 (0.38) | FYNKDM4AKDM5B | |
| SCHEMBL17127854 | 0.68 | HRH4 (0.41) | CNR2 | |
| SCHEMBL18436812 | 0.68 | HRH4 (0.41) | CNR2 | |
| SCHEMBL18436758 | 0.68 | KDM1A (0.34) | EP300MAPK1 | |
| SCHEMBL18436479 | 0.67 | GABRA5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |