Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436101 | 1.00 | HSD11B1 (0.43) | HSD11B1PDE10ACHRM1AOC3HRH3 | |
| SCHEMBL18436275 | 0.88 | PDE10A (0.44) | HSD11B1PDE10ACHRM1HRH3PANK3 | |
| SCHEMBL19012470 | 0.88 | PDE10A (0.44) | HSD11B1PDE10ACHRM1HRH3PANK3 | |
| SCHEMBL18436829 | 0.88 | PDE10A (0.41) | HSD11B1PDE10ACHRM1HRH3PANK3 | |
| SCHEMBL18436007 | 0.88 | PDE10A (0.41) | HSD11B1PDE10ACHRM1HRH3PANK3 | |
| SCHEMBL18436960 | 0.86 | HSD11B1 (0.42) | HSD11B1CHRM1AOC3CHRM2 | |
| SCHEMBL19012569 | 0.84 | HSD11B1 (0.50) | HSD11B1CHRM1AOC3HRH3PANK3 | |
| SCHEMBL19012477 | 0.84 | HSD11B1 (0.50) | HSD11B1CHRM1AOC3HRH3PANK3 | |
| SCHEMBL19012697 | 0.84 | HSD11B1 (0.45) | HSD11B1PDE10ACHRM1HRH3SLC6A9 | |
| SCHEMBL19012381 | 0.84 | HSD11B1 (0.45) | HSD11B1PDE10ACHRM1HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | SMO, GLI1, SHH | HSD11B1 3620/4885PDE10A 1457/4885CHRM1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.