Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17127884 | 1.00 | HRH4 (0.42) | HRH4LRRK2HRH3PRKDCKDM1A | |
| SCHEMBL17128171 | 0.90 | HRH4 (0.40) | HRH4LRRK2KDM1AKDM4EALDH1A1 | |
| SCHEMBL17127837 | 0.90 | HRH4 (0.40) | HRH4LRRK2KDM1AKDM4EALDH1A1 | |
| SCHEMBL17128419 | 0.90 | HRH4 (0.40) | HRH4LRRK2KDM1AKDM4EALDH1A1 | |
| SCHEMBL18436559 | 0.90 | HRH4 (0.40) | HRH4LRRK2KDM1AKDM4EALDH1A1 | |
| SCHEMBL18436454 | 0.90 | HRH4 (0.40) | HRH4LRRK2KDM1AKDM4EALDH1A1 | |
| SCHEMBL21336664 | 0.87 | HRH4 (0.42) | HRH4LRRK2HRH3PRKDCKDM1A | |
| SCHEMBL17127848 | 0.87 | HRH4 (0.42) | HRH4LRRK2HRH3PRKDCKDM1A | |
| SCHEMBL18436706 | 0.87 | HRH4 (0.42) | HRH4LRRK2HRH3PRKDCKDM1A | |
| SCHEMBL17127887 | 0.87 | HRH4 (0.42) | HRH4LRRK2HRH3PRKDCKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |